Faculty of BioMedFarmTekhnological

Faculty of BioMedFarmTekhnological

About FacultyThe ScienceBachelor’sMaster’sPostgraduate’s

Faculty of BioMedFarmTekhnologicalThe new master educational program entered in 2018 at faculty Biomedfarmtekhnological is implemented for training of specialists, biologically active proteinaceous and peptide agents owning fundamental knowledge in design, on release of new proteins and peptides, their synthesis, establishment of spatial structure in solution and a crystal, to studying of biological activity of the natural and modified connections in a broad set of tests.

At the organization of educational process in Branch of institute of bioorganic chemistry of academicians M.M Shemyakin and Yu.A. Ovchinikov RAS (Branch of institute of bioorganic chemistry of  Russian Academy of Sciences) is shared material and technical resources, research and production and intellectual potential of Branch of institute of bioorganic chemistry of Russian Academy of Sciences , including:

  • the laboratory of biological tests (AAALAC International) which is most titled in the country in the field of not clinical trials,
  • the unique station of artificial climate with laboratory of klonalny microreproduction of plants the BIOTRON,
  • scientific-industrial complex for preclinical researches of BIOCENTR medications,
  • environmentally friendly installation for thermal destruction of waste of chemical and biochemical researches.

Considerable attention in the course of training of specialists is paid to training in methods of receiving new medications of the proteinaceous and peptide nature (interferona, new options of hormones of growth, entomotsidny proteins, mutants of limfotoksin, tumor necrosis factor hybrids, etc.) and also to methods of genetic engineering of plants, receiving transgene forms of agricultural cultures with the improved agronomical characteristics, to receptions of an operating time in plants of medicines for the medical and chemical industries (biopharming).

Educational process is carried out with involvement of 4 doctors of the biological and 1 doctor of medical sciences, 2 candidates of biological and 4 Candidates of Chemistry.
During training students work in research laboratories and are involved in implementation of relevant scientific projects.

Main directions of researches:

  • search, allocation, establishment of a structure and synthesis of new biologically active agents – proteins and peptides; studying of molecular mechanisms of their action, interrelation of structure and function;
  • studying of molecular mechanisms of recognition of biomolecules and signaling in biological systems;
  • researches of structure and function of nucleinic acids – genes of the person, animals, plants; expression of genes of biologically important proteins;
  • studying of molecular and cellular fundamentals of immunology – mechanisms of immunomodulatory and antineoplastic activities of natural and synthetic connections;
  • development of new medicines and technologies of their production;
  • preclinical toxicological tests of safety of new biomedications according to the international GLP standard (Good Laboratory Practice) and studying of their pharmacological action;
  • receiving by methods of genetic engineering of transgene plants with the set signs;
  • production of high-quality laboratory animals (mice, rats, hamsters) of category SPF (free from pathogenic flora);
  • creation of biological models of diseases of the person.

Faculty of BioMedFarmTekhnological

Faculty of BioMedFarmTekhnologicalThe main directions of research

– Search, separation, elucidation of structure and synthesis of new biologically active substances – proteins and peptides. The study of the molecular mechanisms of their action, the relationship of structure and function.

– The study of molecular mechanisms of recognition of biomolecules and signaling in biological systems.

– Study the structure and function of nucleic acids – genes of humans, animals, plants. The expression of genes of biologically important proteins.

– The study of the molecular and cellular bases of immunology – mechanisms of immunomodulatory and antitumor activity of natural and synthetic compounds.

Basic and applied biotechnology:

– Development of new drugs and technologies for their production.

– Preclinical toxicology safety testing of new biomedical drugs in accordance with the international standard of GLP (Good Laboratory Practice) and the study of their pharmacological action.

– Getting techniques of genetic engineering transgenic plants with desired characteristics.

– The production of high quality laboratory animals (mice, rats, hamsters) category SPF (free from pathogens).

– The creation of biological models of human diseases.

Achievements, important discoveries/ inventions

– Development of new drugs and technologies for their production.

– Preclinical toxicology safety testing of new biomedical drugs in accordance with the international standard of GLP (Good Laboratory Practice) and the study of their pharmacological action.

– Getting techniques of genetic engineering transgenic plants with desired characteristics.

– The production of high quality laboratory animals (mice, rats, hamsters) category SPF (free from pathogens). The creation of biological models of human diseases.

Lab / departments are involved in educational process

In FIBH RAS includes research laboratories, a unique station of artificial climate with laboratory of clonal micropropagation of plants in the BIOTRON, a research and production complex for preclinical studies of medicines BIOTSENTR and environmentally friendly plant for the thermal destruction of waste chemical and biochemical studies.

Station of artificial climate “Biotron” provides a unique complex allowing to carry out research in the newest fields of plant biotechnology and production of improved planting material, development of modern technologies for growing plants in protected ground.

Currently, the Station “Biotron” studies on the development of methods of obtaining transgenic plants of fruit, berry and ornamental crops with economically valuable traits for the improvement of methods of in vitro cultivation and development of industrial technologies for the production of improved planting material of various agricultural crops. On installation, you can also research on cell engineering, the synthesis of secondary metabolites in callus and suspension cultures.

Laboratory biological testing today is the most titled in Russia in the field of non-clinical studies. Since 2005 she has been accredited by the International Association for assessment and accreditation of work with laboratory animals (AAALAC International). In 2013 the Laboratory received the official recognition of compliance with principles of good laboratory practice (GLP) Slovak national accreditation service (SNAS), which allows to declare that the results of non-clinical studies performed in it can be recognized in the countries belonging to the Organization for economic cooperation and development (EU countries, USA, Canada, etc.). In addition, the Laboratory was the first laboratory, which has received recognition of compliance with GLP principles by the Russian monitoring body –the Federal service for accreditation, and because of this, in Russia, work was completed on the creation of the National system of GLP.

The principal teachers, heads of scientific fields

– Head of laboratory of biological testing dB.N., Professor A. N. Murashev.

Today, the Laboratory in conjunction with life Sciences research Institute of medical Primatology has organized two geographically remote sites. Thus, the center was formed, which performs a full cycle of non-clinical studies GLP. Thanks to this center appeared in Russia the ability to export both the products studied in the centre, and services to conduct non-clinical research, participate in international programs for the study of drugs, pesticides, cosmetic products, veterinary drugs, food and feed additives, chemicals for industrial use.

– Head. artificial climate station “Biotron”, d.b.N. S. V. Dolgov.

One of the key areas of biotechnology research is the creation of various types of transgenic plants with new useful properties for practical use. The main focus is on work in the field of agricultural biotechnology and employing transgenic plants. At station of artificial climate BIOTRON under the guidance of Doct.N. S. V. Dolgov development of methods of plant transformation and genetic engineering techniques to improve their agronomic traits. Achievements of the Branch of the Institute successfully introduced into agricultural practice.

  1. b. Dr. S. V. Dolgov, one of the leaders of research in the field of genetic engineering of plants in Russia. Based on the achieved scientific results, great attention is paid to the production of substances for veterinary and medical use, based on plant expression platforms. In particular, under the leadership of S. V. Dolgov developed expression platform based on tomato for the preparation of recombinant protein svergnutogo of thaumatin II, promising a sweetener for the needs of the pharmaceutical and food industry. The resulting outputs of thaumatin (more than 100mg/kg of fruit of tomato) in order to start scaling technology.

Dolgov, S. V. 1998. he conducts lectures in the course “Biotechnology of plants” in Pushchino State University, lectured at Russian and foreign universities. MSU M. V. Lomonosov, Moscow Institute of physics and technology (MIPT), Russian chemical-technological University named by D. I. Mendeleev (RCTU), the University of Bologna, universities of Sydney, Viterbo (Roman agricultural University).

Dolgov S. V. is a member of several international societies in the field of plant breeding and plant biotechnology ISHS, EUCARPIA, ISPMB, and national correspondent from Russia in IAPB, member of the editorial Board of the journal “Plant Cell, Tissue and Organ Culture” by Springer, a member of the Dissertation Council n D. 006.027.01. Dolgov S. V. took an active part in drafting laws and regulations on the use of genetically modified plants and was an expert of the Interdepartmental Commission on genetic engineering activities.

Current projects: with 2014. in the framework of the grant of the Russian science Foundation (RSF) No. 14-50-00079 directs the creation of a modern complex on biotechnology and bioengineering of plants, fruit and ornamental crops in the Nikitsky Botanical garden in Yalta (national scientific center RAS (NBG-NSC)).

The laboratory is the winner of the fifth contest for a “mega-grants” of 2016 (grant of the Government of the Russian Federation for state support of scientific research carried out under the supervision of leading scientists at Russian universities and scientific organizations, Decree No. 220 of the Government of the Russian Federation). Project title: “New function of the cell nucleus and the complex resistance of potato plants to diseases and physiological stress.” Visiting scholar: Taliansky Mikhail Emmanuilovich (Russia, UK).

– corresponding member cor. RAS, Professor, doctor of agricultural Sciences V. M. Lipkin, head of the laboratory of protein chemistry. In the laboratory, work is underway in several areas of research: a structurally functional study of visual signaling proteins and the development of new approaches to the treatment of multiple sclerosis.

– structural and functional studies of reverin were carried out.  It has been shown that the cellular target of the reverin molecule is rhodopsin kinase.  The study of the mechanism of regulation of the functioning of NQFs due to interaction with the frame protein from the raft structures by caveolin-1 continues.  It was shown that translocation of reverin to photoreceptor raft structures containing caveolin-1 increases the Ca2 + sensitivity of the regulatory activity of the protein, adapting it to the physiological range of changes in the cation concentration in the photoreceptor cell.

– In the laboratory, new approaches are being developed for the production of therapeutic agents for the treatment of multiple sclerosis, biogenic substrates, biogels based on self-organizing peptide fibrils, which are applicable for tissue replacement therapy and as an artificial depot for permanent dose-controlled delivery of drugs to the body.

Faculty of BioMedFarmTekhnological

The faculty prepares bachelors in the direction of 06.03.01 Biology

Profile Biomedicine and Biopharmaceuticals

The development of science and technology leads to the emergence of new professions and specialties at the intersection of scientific areas: medicine, biology, engineering, physics, mathematics, computer science, etc., in particular, biomedicine, biopharmaceuticals, digital biology, biomedical engineering, etc. The successes of modern medicine in  Prevention, diagnosis and treatment of human diseases are determined by the use of innovative drugs and diagnostic methods, the development of which is carried out by scientists and experts in the field of biomedicine and biopharmaceuticals.  Deciphering the human genome has opened up new areas of biomedicine – genomics, proteomics, genetic engineering, 3D – bioprinting, gene diagnostics and gene therapy.  The integration of these achievements with information (digital) and cognitive technologies within the framework of biomedicine opens up the prospect of treating previously considered incurable human diseases.  All these relevant areas of knowledge are included in the undergraduate educational program.

Undergraduate studies are carried out using the unique equipment and laboratory facilities of the academic institutes of the Russian Academy of Sciences.

Full-time form of education

 Duration of study: 4 years (in the presence of a specialized ACT – 3.5 years)

 A hostel and a deferment from the army are provided.

 Admission on a competitive basis according to the results of the exam or entrance tests (biology, chemistry, Russian language)

A graduate who has mastered the undergraduate program “Biology” and has hastily passed the state final certification is awarded the qualification “bachelor” in the direction of preparation 06.03.01 Biology.

Prospects

Bachelor’s graduates will be in demand in scientific and medical medical and diagnostic institutions and high-tech industries that need specialists in the most modern fields of knowledge – digital medicine, genetic analysis for the diagnosis of diseases, translational medicine, regenerative medicine, genetic engineering, tissue engineering and 3D – bioprinting,  pharmaceutical and cell biotechnology.

Graduates who have mastered the undergraduate program will be able to continue their studies in the magistracy in the direction of study “Biology”.

A graduate of a magistracy will become a specialist in one of the relevant areas of biomedical research, demanded by leading scientific laboratories, pharmaceutical and biotechnological companies in Russia, the USA and Europe.  Masters can continue their education in graduate school in biomedical research institutes and universities in the areas of “Biological Sciences”.

The faculty provides training for masters (2 years of study) in the following areas:

06.04.01 Biology 

Biomedfarmtechnology profile

Faculty of BioMedFarmTekhnologicalMaster’s Program – Biomedpharmtechnology

Upon admission to the magistracy, you must pass an exam in biology

The main sections of the program:

– Structural and functional interactions of proteins involved in the regulation of the visual signal.

– The mechanism of action of peptides and pharmaceutical preparations of immunoglobulin origin

– Genetic engineering, protein expression.

– Amino acid analysis, LH and C-terminal analysis, determination of the amino acid sequence of proteins and peptides.

– Interaction of cells with intercellular material.

– Solid-phase synthesis of peptides.

– Enzymatic methylation of plant DNA, artificial programs for the expression of foreign genes in transgenic plants.

– Genetic transformation of various plant species.  Obtaining transgenic plants with new properties of commercial importance.

– The mechanisms of action of pharmaceuticals.

– Screening of the biological activity of natural and synthetic compounds and preclinical studies of the general and specific toxicity of biologically active compounds in accordance with the international GPL standard.

– The study of the processes of resonant energy transfer of bioluminescence photo-proteins.  Development of highly sensitive bioluminescent diagnostic systems, etc.

Molecular Genetic Technology Profile

Faculty of BioMedFarmTekhnologicalMaster’s Program – Molecular Genetic Technology

Upon admission to the magistracy, you must pass an exam in biology

The main sections of the program:

– History and methodology of biology;

– The basic principles of genomics;

– Genome mapping;

– Sequencing strategies, genome annotation;

– Genetic passport-basis of personalized medicine;

– Trakscriptomika;

– Proteomics, global protein analysis, biotechnological basis for the separation of proteomes;

– Fundamentals of modern peptide synthesis;

– DNA technology in the analysis and study of population genetic diversity;

– Molecular genetic markers based on DNA polymorphism;

– Fundamentals of molecular phylogenetics;

– Cloning and transgenesis of animals;

– The use of biological technologies in medicine, cell technology in medicine;

– Medical aspects of human genetics;

– Epigenetics and human diseases;

– The molecular basis of immunology and immunopharmacology;

– Gene therapy;

– Gene-therapeutic approaches to the treatment of hereditary diseases;

– Gene therapy of non-hereditary diseases;

– Biology of tumor growth;

– Gene therapy of malignant diseases;

– Stress and genetic diversity;

– Microbiological production of medicines;

– Microorganisms and animals used to model human diseases.

Graduate students who successfully defend master’s theses can continue their studies in graduate school.

38.04.02 Management

Biotechnological Management profile

Profile “Biotechnological Management”

Faculty of BioMedFarmTekhnological

Faculty of BioMedFarmTekhnological

Master’s Program in Management – Management.  Profile “Biotechnological Management”

Upon admission to the master’s program, it is necessary to pass a management exam

The master’s educational program includes fundamental disciplines in the direction and special courses:

  • Philosophy of Natural Sciences
  • Business English. Professional terminology.
  • Computer technology in science and education
  • Pedagogy
  • Ethics of research and business relations
  • Organization Theory and Organizational Behavior
  • Legal regulation of management activities
  • Patent law and intellectual property management
  • Management Economics
  • Research methods in management
  • Economic analysis
  • Marketing in the field of biotechnology
  • Organization financial management
  • Management accounting of an innovative organization
  • International Management
  • General and strategic management
  • Innovation project management

Disciplines of choice:

  • Basics of biotechnology
  • Biotechnological processes
  • Biotechnology of microorganisms
  • Biopharmaceuticals and biomedicine
  • Advertising, public relations and brand management
  • Business negotiations in management
  • Bioeconomics
  • Modern concepts of biology

Faculty of BioMedFarmTekhnologicalPostgraduate Section

The faculty prepares graduate students (4 years of study) in the direction 06.06.01 Biological sciences in four specialties:

– molecular biology – 03.01.03

– biochemistry – 03.01.04

– bioorganic chemistry – 02.00.10

– pharmacology, clinical pharmacology – 14.03.06

Upon admission to graduate school, it is necessary to pass exams: a special discipline in accordance with the chosen profile, a foreign language.

Postgraduate study in the direction 06.06.01 “Biological Sciences” Specialties:

Biochemistry

Includes educational modules:

– Physicochemical fundamentals of biochemistry

– Enzymatic catalysis

– Molecular mechanisms of biological processes in the cell

– Biochemistry methods

– Storage and sale of genetic information

– Molecular mechanisms of sensory reception

Bioorganic chemistry

Molecular biology

Includes educational modules:

– The structure and biosynthesis of nucleic acids.  Genomics

– The structure and function of proteins.

– The structure of ribosomes and protein biosynthesis.  Protein Engineering

Pharmacology, Clinical Pharmacology

Includes educational modules:

– General pharmacology.

– Medicines that regulate the functions of the peripheral nervous system.

– Means affecting the efferent innervation.

– Means regulating the functions of the central nervous system

– Means regulating the functions of executive bodies

– Means affecting the myometrium, digestion, bleeding

– Means affecting platelet aggregation, blood coagulation and fibrinolysis.

The IBCh RAS has a specialized council for the defense of dissertations.